We are structural biologists concerned with the organization and dynamics of macromolecular assemblies. The long-term objective of our research is to determine how protein interactions determine subcellular structures. We ask the following kinds of questions. (1) How do viruses assemble and how do they enter and exit the cells they infect? (2) Can we combine our understanding of virus structure and entry with contemporary methods for probing the human immune response, to arrive at novel strategies for vaccine design? (3) What is the molecular architecture of a kinetochore? How does this architecture embody its required mechanical and signal-transducing properties?


Viruses Antibody affinity maturation Kinetochores